Colorado vs. USC odds, spread, line: 2023 college football picks, Deion Sanders predictions by proven model

Reigning Heisman Trophy winner Caleb Williams can add to his case to win the award again

when he and the No. 8 USC Trojans face coach Deion Sanders and the Colorado Buffaloes in a Pac-12 game on Saturday at Folsom Field in Boulder,

Co. A 6-foot-1 junior from Washington, D.C., Williams leads the country in several passing categories despite playing just 12 quarters of football.

Williams also has the Trojans (4-0, 2-0 in Pac-12) undefeated and in the hunt for a spot in the College Football Playoffs.

Meanwhile the Buffaloes (3-1, 0-1) already have tripled their win total from last season.

Kickoff is scheduled for noon ET. The Trojans are 21.5-point favorites in the latest USC vs. Colorado odds

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